ACNELINE

ACNELINE is an antibiotic of the family of minocyclines of the Wyeth-Lederle laboratory. For the specialists it is about semi tétracyclines synthetic having a digestive absorption in 90 to 100% and one plasmatic half-life from 12 to 12 midnight.

Indications
Minocycline with the property to concentrate in saliva. This antibiotic is used to treat the individuals carrying germs after an infection with méningocoque.
The genital infections (chlamydia, gonococcus, syphilis) and other diseases (borréliose, brucellosis, rickettsiose, pasteurellose, yersiniose), the infections respiratory (mycoplasmes, psittacosis, fever Q., pneumococcus, streptocoque with haemolytic beta) the leptospirosis, the intestinal amoebiasis (in association with the métronidazole), the cholera, certain affections of the small intestine, the accesses of paludism (in association quinine) and the common acne (with weak amounts in prolonged treatment) call upon the tétracyclines.

Posology
Adult: 200 Mg per day.
Child of more than eight years 4 Mg per kilo and day.

Counter-indications
Allergy to the tétracyclines.
In the child of less than eight years there exists a risk of disorders of osteogenesis (manufacture of bone tissue) and permanent coloring of the teeth.
Renal attack (nephropathy) and risks aggravation of an impaired renal function.
Insufficiency of operation of hepatic gland (liver).
Pregnancy (embryonic risk of toxicity) and breast feeding (the tétracyclines pass in milk).

Undesirable effects
Allergic reaction (itchings, cutaneous eruptions, edema of Quick, ignition of the language with dark coloring of this one, fever, rise in the number of eosinophilic inside blood corresponding a variety of white globules, serum pseudo disease)
Staphylococcic Entérocolite (proliferation of resistant staphilococca sometimes serious) with possibility of bloody diarrhea.
Anorexia.
Nauseas.
Vomiting.
Diarrhea by irritation.
Vestibular disorders with giddinesses nauseas. The hall is the ovoid cavity of form of the osseous labyrinth of the internal ear. This body of the ear plays a big role in the balancing.
Pseudomembraneuse colitis (superinfection difficult Clostridium).
Superinfection by candida (vaginite, candidose intestinal, stomatitis).
Delay of growth of bone tissue.
Permanent coloring of the teeth in the child in eight year old lower part.
Photosensitization (exposure sun is likely to involve the appearance of cutaneous burn and depigmentation of the nails).
Reactional articular attack (minocycline).
Hepatotoxicity (jaundice, hepatic steatosis).
Urologic and nephrologic toxicity (impaired renal function, tubular renal acidosis).
Hypertension inside cranium (benign).

Comment
The tétracyclines must be swallowed with water only. The absorption of milk and products containing of dairy produces as well as antiacids, salts of iron and calcium decrease the absorption of the tétracyclines by the organization.
The individuals suffering from impaired renal function must reduce posology (quantity of drugs taken).
During the treatment it is necessary to avoid the exposure to the sun because there exists a risk of photosensitization to the tétracyclines.
The out-of-date drugs containing of the tétracycline are likely to involve an attack of the kidneys (of Fanconi type) associated with lesions of the skin (érythémateux lupus disseminated).
In the presence of a hyperthyroïdie the administration of tétracycline must be careful.
In the presence of an ulcer duodénal and of myasthénie the tétracyclines can be disadvised.
The tétracyclines are powerful drugs which is not necessary to use for small infections. Indeed, there exists a risk of appearance of resistant stocks.