ACTIFED COLD

ACTIFED COLD
Updated: Thursday, July 22nd, 2010.
Relieving congestion oral: vasoconstrictor, antihistamine and paracetamol
Presentations of drug ACTIFED COLD
ACTIFED COLD: compressed (white); box of 15
Not refunded
Composition of drug ACTIFED COLD
p CP
Triprolidine hydrochlorate 2,5 Mg
Pseudoéphédrine hydrochlorate 60 Mg
Paracetamol 500 Mg

Paracetamol, Pseudoéphédrine hydrochlorate, Triprolidine hydrochlorate
In which case drug ACTIFED COLD is it prescribes?
This drug associates an antihistamine having a draining effect on nasal secretions (triprolidine), a vasoconstrictor relieving congestion (pseudoéphédrine) and of paracetamol, antipyretic and antalgic.

It is used in the symptomatic treatment of the colds with nasal congestion (feeling of stopped nose, nasal flow), headaches or fever.

Counter-indications of drug ACTIFED COLD
This drug should not be used in the following cases:
hepatic insufficiency;

risk glaucome with closed angle;

risk blocking of the urines (adenoma of the prostate);

arterial hypertension not controlled by a specific treatment;

serious coronary insufficiency;

antecedent of convulsions;

antecedent of cerebral vascular accident;

in partnership with an antidepressant of the nonselective type IMAO or during at least 15 days after the catch of this one;

in partnership with another relieving congestion vasoconstrictor or a vasoconstrictor containing one of the following substances: bromocriptine, pergolide, lisuride, cabergoline, ergotamine or dihydroergotamine;

child of less than 15 years;

breast feeding.

Caution
The pseudoéphédrine can cause an acute glaucome at the predisposed people: red eye, hard and painful, with fuzzy vision. A consultation of extreme urgency near an ophthalmologist is necessary.

The relieving congestion vasoconstricteurs can increase the heart rate (tachycardia) and cause palpitations and nauseas. If these undesirable effects are marked too much, the treatment must be stopped.

They can also be responsible for rare complications (convulsions, hallucinations, abnormal agitation), in particular in the event of excessive posology. Respect the recommended amount.

It is preferable to take a medical opinion before using this drug in the event of hyperthyroïdie, of cardiac disease, diabetes, mental health disorders, impaired renal function and in the elderly, in particular in the event of chronic constipation, of tendency to the giddinesses or the falls of tension.

Paracetamol is present alone or in partnership with other substances in many drugs: ensure you simultaneously not to take several drugs containing of paracetamol, because a joint catch involves a risk of overdose which can be toxic for the liver.

Avoid alcoholic drinks: increase in the risk of somnolence.

This drug contains an antihistamine which can induce a somnolence, sometimes intense at certain people. This somnolence can be increased by the catch of alcohol or other sedative drugs. You at the time of the first catches ensure that you support it well, before leading or using a dangerous machine.

Sportsman: this drug contains a substance considered as stimulative (phényléphrine, pseudoéphédrine or synéphrine) which appears in the monitoring program 2004 of the ministry for Youth and the Sports. It can be required in the urines of the sportsmen in order to detect possible a mésusage.

Interactions of drug ACTIFED COLD with other substances
This drug should not be associated with the antidepressants of the nonselective type IMAO (MARSILID…), with another relieving congestion vasoconstrictor or a vasoconstrictor used in the Parkinson’s disease (bromocriptine, pergolide, lisuride, cabergoline) or in the migraine (ergotamine, dihydroergotamine). Association with these drugs is likely to cause a hypertensive crisis.

In addition inform your pharmacist or your doctor if you take drugs sedative or atropinic.

In the event of treatment by an oral anticoagulant and paracetamol with the maximum amounts (4 G per day) during at least 4 days, an heightened surveillance of the anticoagulant treatment will be possibly necessary.

Pregnancy and breast feeding
Pregnancy:
Because of the presence of pseudoéphédrine, the use of this drug is disadvised in the expectant mother.

Breast feeding:
This drug passes in the mother’s milk. It is contra-indicated during breast feeding.

Directions for use and posology of drug ACTIFED COLD
The tablets must be swallowed without being crunched with water glass, by respecting 6 hours a minimal interval between the catches. In the event of serious impaired renal function, it is necessary to space the catches of at least 8 hours.

Usual posology:
Adult and child of more than 15 years: 1 compressed, 1 to 3 times per day.

The Councils
This drug does not have an anti-infectious effect. If the disorders persist more than 5 days, to consult your doctor.

Possible undesirable effects of drug ACTIFED COLD
Somnolence or insomnia: the antihistamine is sedative whereas the vasoconstrictor can present an exciting effect. According to the people, one or the other of these effects can prevail.

Dryness of the mouth, constipation, disorders of accommodation, retention of the urines.

Orthostatic hypotension, disorders of balance, giddinesses, tremors, agitation, confusion of the ideas in particular in the elderly.

Palpitations, tachycardia, anxiety, headaches, sweats, nauseas, vomiting.

Allergic reaction, anomaly of numeration formulates blood.

Laboratory Mc Neil Health General public
LEXICON
cerebral vascular accident
Lesion of the brain due to a hemorrhage or the brutal obstruction of an artery. According to the importance of the lesion, the consequences are more or less serious: temporary malaise, paralysis, coma.

Abbreviation: AVC.

accommodation
“Developed” of the eye, allowing the clear vision of near. Presbyopia is the disorder of accommodation more running; certain drugs such as the atropine can cause momentary disorders of accommodation.

adenoma of the prostate
Increase in the volume of the prostate, gland located under the bladder of the man. This increase in volume is benign, does not have any relationship with a cancer, but can obstruct the passage of the urines in the channel (urethra) which crosses gland.

The symptoms which make evoke the presence of an adenoma of the prostate are:
a difficulty of urinating (slowness, weakness of the jet);

the need to rise several times the night to urinate;

desires for urinating pressing and difficult to control.

Certain drugs, the atropiniques ones in particular, can have as an undesirable effect worsening the embarrassment and can lead to a total blocking of the evacuation of the bladder. They are thus contra-indicated or must be used prudently at the men presenting the symptoms described above.

alcohol
General name designating a family of substances which have the property to be able to be mixed with water and the greasy substances. Alcohol more the current is the ethanol (ethanol), but there exist many other alcohols: methanol, butanol, etc the degree of an alcoholic solution corresponds to the volume of pure alcohol present in 100 ml of solution, by knowing that 1 balloon glass of wine or 1 beer half (25 Cl) contains approximately 8 G of alcohol.

When alcohol is used as disinfectant, an unpleasant denaturing agent of odor is often added to him to prevent that he is drunk. Contrary to a spread belief, alcohol with 70o (or even with 60o) is a better disinfectant than alcohol with 90o.

analgesics
Drug which acts against the pain. Analgesics act either directly on the centers of the pain located in the brain, or by blocking the transmission of the pain to the brain.

Synonym: analgesic.

antecedent
Affection cured or always in evolution. The antecedent can be personal or family. The antecedents constitute the history of the health of a person.

anticoagulant
Drug which prevents blood from coagulating and which thus prevents the formation of clots in the blood-vessels.

The anticoagulants are used to treat or prevent the phlebites, the pulmonary embolisms, certain infarctions. They also make it possible to prevent the formation of clots in the heart at the time of disorders of the rate/rhythm like auricular fibrillation or in the event of artificial cardiac valve.

There exists two large types of anticoagulants:
the oral anticoagulants, which block the action of the vitamin K (antivitamine K, or AVK) and whose effectiveness is controlled by a blood proportioning: INR (in the past TP);

injectable anticoagulants, derived from the heparin, whose effectiveness can be controlled by the blood proportioning of the anti-Xa activity, the Time of Howell (TH) or the Time of Cephalin Kaolin (TCK) according to the products used. A regular proportioning of the blood plates is necessary during all the utilization period of a derivative of heparin.

antidepressant
Drug which acts against the depression. Certain antidepressants are also used to fight the obsessional disorders compulsifs, the generalized anxiety, certain rebellious pains, the enuresis, etc

According to their mode of action and their undesirable effects, the antidepressants are divided into various families: the antidepressants imipraminic, the inhibiters of recaptures serotonin, the IMAO (selective or not selective). Lastly, other antidepressants do not belong to any of these families, because they have original properties.

The mode of action of the antidepressants comprises two principal aspects: relief of mental anguish and the fight against the inhibition which removes any will of action with depressed. It happens that a shift occurs between these two effects: mental anguish can persist, whereas the capacity of action reappears. For this short period, the suicidal risk present at some depressed can be increased. The doctor holds of it account in his regulation (possible association with one tranquillizing) and this one must be imperatively respected.

antihistamine
Drug which is opposed to the various effects of histamine. Two principal types exist: antihistamines of the H1 type (antiallergic) and antihistamines of the type H2 (antiulcéreux gastric). Certain antihistamines of the H1 type are sedative, others do not deteriorate vigilance.

antipyretic
Drug used to lower the temperature of the body at the time of the accesses of fever.

atropinic
Drug to which the effects are close to those of the atropine. The atropiniques ones fight against the spasms and the diarrhea. The undesirable effects of atropinic are the following: thickening of bronchial secretions, dryness of the mouth and the mucous membranes, constipation, risk of acute blocking of the urines and crisis of glaucome at the predisposed, turbid people of accommodation, abnormal sensitivity to the light by dilation of the pupil. The catch of several drugs atropinic increases the risk of undesirable effects. In the event of overdose or of accidental ingestion, can also appear the following signs: red and hot skin, fever, acceleration of breathing, drop or, on the contrary, rise in the blood-pressure, agitation, hallucinations, bad coordination of the movements. Warn your doctor urgently or, failing this, call the 15, the 112 or one emergency medical department.

In addition to the atropine and its derivatives, other drugs present effects atropinic: antidepressants imipraminic, certain antihistamines, antispasmodic, antiparkinsoniens and nerve sedatives.

convulsions
Involuntary contractions limited to some muscles or generalized with all the body. They are due to a suffering or an excessive stimulation of the brain: fever, intoxication, lack of oxygen, lesion of the brain. The convulsions can be due to an epileptic fit or a fever raised in the young child.

diabetes
General term indicating the diseases resulting by the emission of abundant urines and an intense thirst. Employee alone, the word diabetes generally relates to the sweetened diabetes, which corresponds to a disturbance of the regulation of sugars of the organization by insulin. He results by the increase in sugar (glucose) in blood and in his possible presence in the urines. There exist two kinds of sweetened diabetes: diabetes of the type 1, or insulinodépendant, which requires a treatment by insulin in injection, and diabetes of the type 2, or not insulinodépendant, which can, initially, being treated by antidiabetic the oral examinations.

glaucome
Disease characterized by the increase in the pressure of the liquids contained in the eye (hypertension intraoculaire).

This general term recovers two completely different affections:
The glaucome with open angle or glaucome chronic is most frequent; it without symptoms, is generally detected by the measurement of the tension intraoculaire in the ophthalmologist. It does not cause an acute crisis, and the treatment rests primarily on eye lotions beat-blockings. The people reached of a glaucome with open angle should not use derivatives of cortisone without preliminary ophthalmologic opinion.

The glaucome with angle closed or glaucome acute is rarer. Between the crises, the tension intraoculaire is normal. But the inopportune use of drugs atropinic (in particular in eye lotion) causes an acute crisis of hypertension intraoculaire which can definitively damage the retina in a few hours. It is an ophthalmologic urgency which is recognized in an eye brutally red, awfully painful, hard like a ball of glass, and whose vision becomes fuzzy.

The angle of which it is question in these two affections is the irido-corneal angle. It is indeed between the iris and the cornea that the system of evacuation of the liquids of the eye is. A not very open angle (closed) exposes to a total obstruction of the system of evacuation. This obstruction can occur when the iris is opened to the maximum (mydriase) under the effect of a drug atropinic: the iris then comes to be joined with the cornea.

The atropinic counter-indications of the drugs concern only the people having already made crises of glaucome with closed angle, or at which an ophthalmologist detected this risk. Those which suffer from a chronic glaucome with open angle are not concerned with these counter-indications.

arterial hypertension
Excess of pressure (tension) of blood in the arteries. This pressure is ensured by the heart and is expressed by two digits. It is maximum at the time of the contraction of the heart, or systole (first figure), and minimal at the time of the cardiac rest, or diastole (second figure). An arterial hypertension is characterized by a maximum pressure (systolic) higher or equalizes to 16, or a minimal pressure (diastolic) higher or equalizes to 9,5. A treatment is founded when these figures are exceeded or for weaker tensions at certain people presenting of the risk factors cardiovascular: heredity, nicotinism, diabetes, excess of cholesterol. Permanent a antihypertensor treatment makes it possible to limit the damage of the heart and the blood-vessels due to arterial hypertension.

hyperthyroïdie
Excess of thyroid hormones resulting in particular in an acceleration of the heart, a bad tolerance with heat, a slimming and a chronic tiredness.

orthostatic hypotension
Lower blood-pressure upright occurring at the time of the passage of the reclining position with the position. Generally had with drugs, orthostatic hypotension results in dizzy spells with risk of fall, in particular in the elderly. One can prevent these disorders by avoiding the brutal changes of position: to remain sitted a few moments at the edge of the bed before putting themselves upright, slowly rising seat by keeping a support before moving.

The port of bottom of application, which prevents blood from ebbing towards the legs in position upright, is also used to treat orthostatic hypotension.

IMAO
Abbreviation of inhibiter of the mono-amine-oxydase. Family of drugs used in psychiatry and neurology (depression, Parkinson’s disease). These drugs are divided into two types: the nonselective IMAO, which are incompatible with many drugs and even certain food, and the selective IMAO (have or B), for which these disadvantages absent or are limited.

coronary insufficiency
Disablement partial of the arteries of the heart (coronary arteries) to irrigate the cardiac muscle. Crises of angina pectoris can occur, generally at the time of an effort.

hepatic insufficiency
Incapacity of the liver to fulfill its function, which is primarily the elimination of certain waste, but also the synthesis of many biological substances essential to the organization: albumin, cholesterol and factors of coagulation (vitamin K, etc).

impaired renal function
Incapacity of the kidneys to eliminate waste or the medicamentous substances. A advanced impaired renal function does not result inevitably in a reduction in the quantity of eliminated urine. Only a blood test and the proportioning of creatinin can reveal this disease.

mucous membrane
Fabric (membrane) which papers the cavities and the conduits of the body communicating with outside (digestive tract, breathing apparatus, urinary tracts, etc).

numeration formulates blood
Numeration measures the number of red globules (red blood corpuscles), white globules (leucocytes) and plates in blood. The blood picture specifies the percentage of the various white globules: neutrophiles, eosinophilic, basophilic, lymphocytes, monocytes.

Abbreviation: NFS.

palpitations
Abnormal perception of irregular cardiac beats.

posology
Quantity and distribution of the amount of a drug according to the age, of the weight and the general state of the patient.

allergic reaction
Reaction due to the over-sensitiveness of the organization to a drug. The allergic reactions can take very varied aspects: urticaria, edema of Quincke, eczema, eruption of buttons pointing out measles, etc the shock anaphylactic is a generalized allergic reaction which causes a faintness by sharp decline of the blood-pressure.

sedative
Who alleviates, who calms.

Drug pertaining to various families: anxiolytic, hypnotic, antalgic, cough mixtures, antiepileptic, nerve sedatives, etc but also antidepressants, H1 antihistamines, antihypertenseurs. A sedative can be responsible for somnolence and increase the effects of alcohol.

physiological salt solution
Salt water (sodium chloride) to 9 G per liter, whose current name is physiological aqueous solution. This concentration, which approaches that of blood and the lymph, is perfectly compatible with biological fabrics. The physiological salt solution is used for washings, the irrigations and the injections (in this last case, it must be sterile).

overdose
The catch in excessive quantity of a drug exposes to an increase in the intensity of the undesirable effects, even with the appearance of particular undesirable effects.

This overdose can result from an accidental, or voluntary intoxication with an aim of suicide: it is then advisable to consult the poisons center of your area (list in appendix of the work). But generally, the overdose is the consequence of an error in the comprehension of the ordinance, or the search for an increase in the effectiveness by a going beyond of recommended posology. Lastly, an inopportune self medication can lead to absorption in excessive quantity of the same substance contained in different drugs. Certain drugs expose more particularly at this risk, because they are regarded (wrongly) as pain-killers: vitamins has and D, aspirine, etc the stop or the reduction in the medicamentous catches make it possible to make disappear the disorders related to an overdose.

tachycardia
Acceleration of the rate/rhythm of the beats of the heart. It can be due to a fever, a hyperthyroïdie, a cardiac disease, the action of certain drugs, etc

symptomatic treatment
Treatment which removes or attenuates the symptoms of a disease without attacking its cause.

vasoconstrictor
Drug which causes a contraction of the blood-vessels, in opposition to vasodilator.

giddiness
Symptom which can indicate an impression of loss of balance (common direction) or, more strictly, a feeling of rotation on oneself or the environment (medical direction).